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Leonard J Appleman Selected Research

belzutifan

10/2021Author Correction: Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis.
1/2021Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis.

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Leonard J Appleman Research Topics

Disease

22Neoplasms (Cancer)
01/2022 - 11/2005
18Renal Cell Carcinoma (Grawitz Tumor)
01/2022 - 12/2009
7Prostatic Neoplasms (Prostate Cancer)
01/2022 - 12/2010
5Fatigue
10/2020 - 11/2005
4Vomiting
12/2019 - 11/2005
4Nausea
12/2019 - 11/2005
3Hypoxia (Hypoxemia)
10/2021 - 12/2019
3Neoplasm Metastasis (Metastasis)
01/2021 - 10/2018
3Anemia
10/2020 - 11/2005
3Neutropenia
01/2020 - 12/2006
3Thrombocytopenia (Thrombopenia)
12/2019 - 11/2006
3Diarrhea
06/2014 - 11/2005
2Lung Neoplasms (Lung Cancer)
12/2019 - 12/2006
2Pancreatic Neoplasms (Pancreatic Cancer)
12/2019 - 12/2006
1Lymphopenia (Lymphocytopenia)
10/2021
1Carcinogenesis
01/2021
1Urinary Tract Infections (Urinary Tract Infection)
10/2020
1Carcinoma (Carcinomatosis)
10/2020
1Circulating Neoplastic Cells
01/2020
1Hyponatremia
12/2019
1Breast Neoplasms (Breast Cancer)
12/2019
1Dizziness (Lightheadedness)
12/2019
1Febrile Neutropenia
12/2019
1Hypersensitivity (Allergy)
12/2019
1Peripheral Nervous System Diseases (PNS Diseases)
12/2019
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2019
1Asymptomatic Diseases
01/2016

Drug/Important Bio-Agent (IBA)

5Pharmaceutical PreparationsIBA
01/2022 - 11/2005
4Biomarkers (Surrogate Marker)IBA
10/2021 - 06/2014
3Immune Checkpoint InhibitorsIBA
01/2022 - 10/2016
3AntigensIBA
01/2020 - 10/2013
3EverolimusFDA Link
01/2019 - 10/2016
3Phosphotransferases (Kinase)IBA
10/2018 - 04/2011
2pembrolizumabIBA
01/2022 - 10/2020
2abirateroneIBA
01/2022 - 01/2020
2enzalutamideIBA
01/2022 - 01/2020
2AndrogensIBA
01/2022 - 01/2021
2belzutifanIBA
10/2021 - 01/2021
2ElectrolytesIBA
10/2021 - 01/2020
2Radium-223IBA
01/2021 - 01/2016
2Antineoplastic Agents (Antineoplastics)IBA
05/2019 - 11/2015
2NivolumabIBA
01/2018 - 10/2016
2Doxorubicin (Adriamycin)FDA LinkGeneric
06/2014 - 01/2014
2Methotrexate (Mexate)FDA LinkGeneric
06/2014 - 01/2014
2Vinblastine (Vinblastine Sulfate)FDA Link
06/2014 - 01/2014
2Cisplatin (Platino)FDA LinkGeneric
06/2014 - 01/2014
2Sunitinib (Sutent)FDA Link
06/2014 - 12/2011
2Sorafenib (BAY 43-9006)FDA Link
06/2014 - 04/2011
2Bortezomib (Velcade)FDA Link
12/2006 - 11/2006
1SteroidsIBA
01/2022
1Docetaxel (Taxotere)FDA Link
01/2022
1HLA-A Antigens (HLA-A)IBA
01/2022
1Prednisone (Sone)FDA LinkGeneric
01/2022
1Bevacizumab (Avastin)FDA Link
10/2021
1ARQ 197IBA
10/2021
1atezolizumabIBA
01/2021
1Transcription Factors (Transcription Factor)IBA
01/2021
1PlatinumIBA
10/2020
1acalabrutinibIBA
10/2020
1Alanine Transaminase (SGPT)IBA
10/2020
1Programmed Cell Death 1 ReceptorIBA
10/2020
1Prostate-Specific Antigen (Semenogelase)IBA
01/2020
1PSMA ADCIBA
01/2020
1Cytotoxins (Cytolysins)IBA
12/2019
1Histone Deacetylase InhibitorsIBA
12/2019
1Paclitaxel (Taxol)FDA LinkGeneric
12/2019
1Carboplatin (JM8)FDA LinkGeneric
12/2019
1Isotretinoin (Accutane)FDA LinkGeneric
12/2019
1Tretinoin (Retinoic Acid)FDA LinkGeneric
12/2019
1belinostatIBA
12/2019
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2019
1veliparibIBA
12/2019
1Poly(ADP-ribose) Polymerase InhibitorsIBA
12/2019
1vasectrin I (VS I)IBA
01/2019
1MTOR InhibitorsIBA
01/2019
1Hydroxychloroquine (Plaquenil)FDA LinkGeneric
01/2019
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
10/2018
1cabozantinibIBA
10/2018
1Tyrosine (L-Tyrosine)FDA Link
10/2018
1TOR Serine-Threonine KinasesIBA
01/2017
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2017
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2017
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2017
1Interleukin-2 (IL2)IBA
01/2017
1RNA (Ribonucleic Acid)IBA
10/2016
1Immunosuppressive Agents (Immunosuppressants)IBA
10/2016
1phenethyl isothiocyanate (PEITC)IBA
11/2015
1benzyl isothiocyanateIBA
11/2015
1sulforaphaneIBA
11/2015
1IsothiocyanatesIBA
11/2015
1NSC281612IBA
02/2015
1pegfilgrastim (Neulasta)FDA Link
06/2014

Therapy/Procedure

14Therapeutics
01/2022 - 12/2009
4Drug Therapy (Chemotherapy)
01/2022 - 01/2014
4Immunotherapy
01/2022 - 10/2016
4Castration
01/2022 - 12/2010
1Neoadjuvant Therapy
01/2019
1Nephrectomy
01/2019
1Metastasectomy
01/2018
1Chemoprevention
11/2015